Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development
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چکیده
منابع مشابه
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.
Transcription factor control of cell-specific downstream targets can be significantly altered when the controlling factor is mutated. We show that the semi-dominant neonatal anemia (Nan) mutation in the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in ...
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ژورنال
عنوان ژورنال: Development
سال: 2017
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.145656